Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

These methods describe how to formulate injectable, supramolecular polymer-nanoparticle (PNP) hydrogels for use as biomaterials. PNP are composed of two components: hydrophobically modified cellulose the network polymer and self-assembled core-shell nanoparticles that act non-covalent cross linkers through dynamic, multivalent interactions. both formation these nanoprecipitation well formulation mixing components form with tunable mechanical properties. The dynamic light scattering (DLS) rheology characterize quality synthesized materials is also detailed. Finally, utility drug delivery, biopharmaceutical stabilization, cell encapsulation delivery demonstrated in vitro experiments release, thermal stability, settling viability. Due its biocompatibility, injectability, mild gel conditions, this hydrogel system a readily platform suitable range biomedical applications.